Emergence and Evolution of the Circadian Rhythm of Melatonin in Children

@article{Ardura2003EmergenceAE,
  title={Emergence and Evolution of the Circadian Rhythm of Melatonin in Children},
  author={Julio Ardura and Regina Isabel Hern{\'a}ndez Guti{\'e}rrez and Jes{\'u}s Andr{\'e}s and Teresa Agapito},
  journal={Hormone Research in Paediatrics},
  year={2003},
  volume={59},
  pages={66 - 72}
}
Objective: To assess the age at which the circadian rhythm of melatonin begins. Methods: 55 children, divided into groups from the neonatal period to 24 months of life, were studied. Urine samples were taken from 28 newborn babies to measure 6-sulfatoxymelatonin (aMT6s). Salivary samples were collected from infants (27 cases), to measure melatonin (aMT). aMT was measured by RIA and aMT6s by ELISA using commercial kits. Changes in the levels of aMT6s and aMT were evaluated using the Friedman… 

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