Emergence and Evolution of the Circadian Rhythm of Melatonin in Children

@article{Ardura2003EmergenceAE,
  title={Emergence and Evolution of the Circadian Rhythm of Melatonin in Children},
  author={J. Ardura and R. Guti{\'e}rrez and J. Andr{\'e}s and T. Agapito},
  journal={Hormone Research in Paediatrics},
  year={2003},
  volume={59},
  pages={66 - 72}
}
Objective: To assess the age at which the circadian rhythm of melatonin begins. Methods: 55 children, divided into groups from the neonatal period to 24 months of life, were studied. Urine samples were taken from 28 newborn babies to measure 6-sulfatoxymelatonin (aMT6s). Salivary samples were collected from infants (27 cases), to measure melatonin (aMT). aMT was measured by RIA and aMT6s by ELISA using commercial kits. Changes in the levels of aMT6s and aMT were evaluated using the Friedman… Expand
Diurnal melatonin patterns in children: ready to apply in clinical practice?
TLDR
The high interindividual variability of diurnal melatonin concentrations challenges clinical applications in regard to diagnostic purposes and the criteria for initiating exogenous melatonin therapy. Expand
The circadian rhythm of tryptophan in breast milk affects the rhythms of 6-sulfatoxymelatonin and sleep in newborn.
TLDR
A temporal relationship was observed between the circadian rhythm of 6-sulfatoxymelatonin of the exclusively breast-fed babies and that of tryptophan in the mother's milk, and assumed sleep, actual sleep, and sleep efficiency were significantly increased in the breast fed infants with respect the formula fed infants. Expand
Daily Profiles of Salivary and Urinary Melatonin and Steroids in Healthy Prepubertal Boys
TLDR
This study shows the relevance of salivary cortisol and melatonin, although lower than in plasma, in testing adrenal and pineal function as markers of circadian rhythms in prepubertal children. Expand
Melatonin Levels during the First Week of Life and Their Relation with the Antioxidant Response in the Perinatal Period
TLDR
In newborns of low birthweight, high melatonin concentrations in the morning and during the first week of life are reported, which seem to derive from extrapineal sources, which mature to provide antioxidant protection in accordance with other elements of the antioxidant network to compensate for the high levels of oxidative stress that are present in the perinatal period. Expand
Melatonin in Epilepsy and Febrile Seizures
TLDR
The data support the presence of diurnal rhythm in blood melatonin concentrations in children with epileptic and febrile seizures and showed lower peak concentrations in the febRIle seizure group with respect to healthy controls. Expand
Sleep Biological Rhythms in Normal Infants and those at High Risk for SIDS
TLDR
Data analyses indicate that ultradian REM/NREM cyclicity becomes stabilized into a regular pattern at three months of age, and differences during the early morning hours, when the occurrence of SIDS peaks, may have important implications for understanding the pathophysiological mechanism of Sids. Expand
Circadian Variation in Human Milk Composition, a Systematic Review
TLDR
Major circadian variation is found in tryptophan, fats, triacylglycerol, cholesterol, iron, melatonin, cortisol, and cortisone, which may play a role in the child’s growth and development in terms of the biological clock. Expand
Improved circadian sleep-wake cycle in infants fed a day/night dissociated formula milk.
TLDR
The use of a chronobiologically adjusted infant formula milk seems to be effective in improving the consolidation of the circadian sleep/wake cycle in bottle-fed infants. Expand
Endocrine and neurophysiological examination of sleep disorders in Williams syndrome
Background: A high rate of sleep disturbances have been reported in individuals with Williams syndrome (WS), but the underlying aetiology has yet to be identified. Melatonin and cortisol levels areExpand
Mother-infant circadian rhythm: development of individual patterns and dyadic synchrony.
TLDR
Development of mother-infant synchrony reflects shared elements of circadian rhythm, and infants demonstrated a developmental trajectory of circadian pattern with significant time effects for increasing mesor, magnitude, amplitude, L5, IS, and IV. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 34 REFERENCES
Absence of plasma melatonin circadian rhythm during the first 72 hours of life in human infants.
TLDR
The results suggest that the pineal gland in the neonate actively secretes MT, but not in a rhythmic manner, implying that the circadian rhythm of MT described previously in cord blood is a reflection of the maternal rhythm. Expand
Similarity of the nocturnal profile of serum melatonin at early puberty and early adulthood.
TLDR
The findings do not support the view that MT concentrations fall at the beginning of pubertal development and that changes in body size may be the reason for age-dependent changes of serum MT concentrations. Expand
Plasma and urinary melatonin in male infants during the first 12 months of life
TLDR
It is demonstrated that plasma MEL is low at the time of post natal T and LH rise in male infants and increases later when testicular activity falls, which is opposite to that of melatonin. Expand
Nocturnal melatonin patterns in children.
TLDR
Associations with gender, body mass index, and chronological and pubertal age determined by multiple linear regression and ANOVA reveal that the area under the curve of 12-h melatonin concentrations was affected by Pubertal rather than chronological age, an effect to which data collected during darkness contributed the most. Expand
The development of circadian rhythms in a human infant.
TLDR
Circadian rhythms appeared much more rapidly in this infant than previously reported; their rapid appearance was probably facilitated by maximal exposure to sunlight, and regular social cues. Expand
Ontogeny of Circadian Rhythmicity for Melatonin, Serotonin, and N‐Acetylserotonin in Humans
TLDR
The results indicate that in humans the circadian organizatijon for serotonin already exists at birth, and the circadian melatonin rhythm develops after birth. Expand
MELATONIN IN INFANTS AND MOTHERS AT DELIVERY AND IN INFANTS DURING THE FIRST WEEK OF LIFE
TLDR
The results show that infant MT immediately after delivery at least partly reflects maternal MT secretion, and the diurnal rhythm of MT is not yet developed, possibly because of the inability of the pineal gland to react to external stimuli at this stage, or because increased secretion of gonadotrophins after delivery suppresses the pineAL gland. Expand
The Effect of Light on Plasma Melatonin Levels in Premature Infants
TLDR
The results indicate that at this gestational age the pineal gland is actively secreting melatonin but does not respond to the light alternations attempted. Expand
Development of melatonin production in infants and the impact of prematurity.
TLDR
Evidence is provided that neural centers responsible for rhythm generation and/or the pineal gland fail to accelerate their development after premature delivery, and this may be due to the environment the infants are exposed to during their stay in hospital. Expand
Daily and seasonal variations in the concentration of melatonin in the human pineal gland
TLDR
The data indicate that the concentration of melatonin in the human pineal is augmented only during the long photoperiod, which may result from living in an artificial light environment or due to other nonphotic signals involved in generating melatonin rhythm. Expand
...
1
2
3
4
...