Emergence, spread, and environmental effect of antimicrobial resistance: how use of an antimicrobial anywhere can increase resistance to any antimicrobial anywhere else.

@article{Obrien2002EmergenceSA,
  title={Emergence, spread, and environmental effect of antimicrobial resistance: how use of an antimicrobial anywhere can increase resistance to any antimicrobial anywhere else.},
  author={Thomas F. O'brien},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2002},
  volume={34 Suppl 3},
  pages={
          S78-84
        }
}
Use of an antimicrobial agent selects for overgrowth of a bacterial strain that has a gene expressing resistance to the agent. It also selects for the assembly and evolution of complex genetic vectors encoding, expressing, linking, and spreading that and other resistance genes. Once evolved, a competitive construct of such genetic elements may spread widely through the world's bacterial populations. A bacterial isolate at any place may thus be resistant-not only because nearby use of… CONTINUE READING
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