Embryotoxicant-specific transcriptomic responses in rat postimplantation whole-embryo culture.

Abstract

Rat postimplantation whole-embryo culture (WEC) is a promising alternative test for the assessment of developmental toxicity. Toxicogenomic-based approaches may improve the predictive ability of the WEC model by providing a means to identify compound-specific mechanistic responses associated with embryotoxicity in vivo. Furthermore, alterations in gene… (More)
DOI: 10.1093/toxsci/kfq292

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