Embryopathic effects of diazoxide and the reduction of sulfonylurea-induced dysmorphogenesis in vitro.


Diazoxide is a benzothiadiazine used in oral and intravenous preparations to treat hypertension and hypoglycaemia, but its effect on embryonic development has not been well studied. Previous in vivo work has suggested placental transfer and teratogenicity of diazoxide in humans and laboratory animals, but this study represents the first in vitro… (More)