Embryonic vascular disruption adverse outcomes: Linking high-throughput signaling signatures with functional consequences.


Embryonic vascular disruption is an important adverse outcome pathway (AOP) as chemical disruption of cardiovascular development induces broad prenatal defects. High-throughput screening (HTS) assays aid AOP development although linking in vitro data to in vivo apical endpoints remains challenging. This study evaluated two anti-angiogenic agents, 5HPP-33… (More)
DOI: 10.1016/j.reprotox.2017.04.003