Embryonic turkey liver: activities of biotransformation enzymes and activation of DNA-reactive carcinogens

@article{Perrone2004EmbryonicTL,
  title={Embryonic turkey liver: activities of biotransformation enzymes and activation of DNA-reactive carcinogens},
  author={Carmen E. Perrone and Hans-J{\"u}rgen Ahr and Jian Dong Duan and Alan M. Jeffrey and Ulrich Schmidt and Gary M Williams and Harald H. Enzmann},
  journal={Archives of Toxicology},
  year={2004},
  volume={78},
  pages={589-598}
}
Avian embryos are a potential alternative model for chemical toxicity and carcinogenicity research. Because the toxic and carcinogenic effects of some chemicals depend on bioactivation, activities of biotransformation enzymes and formation of DNA adducts in embryonic turkey liver were examined. Biochemical analyses of 22-day in ovo turkey liver post-mitochondrial fractions revealed activities of the biotransformation enzymes 7-ethoxycoumarin de-ethylase (ECOD), 7-ethoxyresorufin de-ethylase… CONTINUE READING
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