Embryonic stress hypothesis of teratogenesis.

  title={Embryonic stress hypothesis of teratogenesis.},
  author={James German},
  journal={The American journal of medicine},
  volume={76 2},
  • James German
  • Published 1984 in The American journal of medicine
Cells and tissues of essentially all eukaryotes respond uniformly to a variety of stressful situations. Immediately following the onset of several types of environmental insult (e.g., hyperthermia), genes for the so-called heat-shock proteins become unusually active; simultaneously, other genetic loci that were engaged in transcription at the onset of the insult become relatively less active. The biologic significance of the heat-shock response is unknown, as is its role, if any, in maintaining… CONTINUE READING