Embryonic stem cells with GFP knocked into the dopamine transporter yield purified dopamine neurons in vitro and from knock-in mice.

@article{Zhou2009EmbryonicSC,
  title={Embryonic stem cells with GFP knocked into the dopamine transporter yield purified dopamine neurons in vitro and from knock-in mice.},
  author={Wenbo Zhou and Young Mook Lee and Vanessa C. Guy and Curt R. Freed},
  journal={Stem cells},
  year={2009},
  volume={27 12},
  pages={2952-61}
}
Parkinson's disease (PD) is characterized by the selective loss of midbrain dopamine neurons. Neural transplantation with fetal dopamine neurons can be an effective therapy for patients with PD, but recovery of human fetal cells is difficult. Scarcity of tissue has limited clinical application to a small number of research subjects worldwide. Selective differentiation of embryonic stem cells (ESCs) to dopamine neurons could lead to an unlimited supply of cells for expanded clinical… CONTINUE READING
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