Embryonic stem cells induce pluripotency in somatic cell fusion through biphasic reprogramming.

@article{Foshay2012EmbryonicSC,
  title={Embryonic stem cells induce pluripotency in somatic cell fusion through biphasic reprogramming.},
  author={Kara M Foshay and Timothy J. Looney and Sheila Chari and Frank Fuxiang Mao and Jae Hyun Lee and Li Zhang and Croydon J. Fernandes and Samuel W. Baker and Kayla L. Clift and Jedidiah Gaetz and Chun-Guang Di and Andy Peng Xiang and Bruce T. Lahn},
  journal={Molecular cell},
  year={2012},
  volume={46 2},
  pages={159-70}
}
It is a long-held paradigm that cell fusion reprograms gene expression but the extent of reprogramming and whether it is affected by the cell types employed remain unknown. We recently showed that the silencing of somatic genes is attributable to either trans-acting cellular environment or cis-acting chromatin context. Here, we examine how trans- versus cis-silenced genes in a somatic cell type behave in fusions to another somatic cell type or to embryonic stem cells (ESCs). We demonstrate that… CONTINUE READING
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