Embryonic stem cells and transgenic mice in the study of hematopoiesis.

@article{Orkin1998EmbryonicSC,
  title={Embryonic stem cells and transgenic mice in the study of hematopoiesis.},
  author={Stuart H Orkin},
  journal={The International journal of developmental biology},
  year={1998},
  volume={42 7},
  pages={927-34}
}
  • Stuart H Orkin
  • Published 1998 in
    The International journal of developmental…
Blood formation (hematopoiesis) entails the generation of hematopoietic stem cells (HSCs) within the embryo and subsequent commitment of multipotential progenitors to differentiation along single lineages. These processes are controlled in large part by cell-restricted transcription factors which cooperate with more widely expressed factors to direct lineage-specific gene expression. Candidate hematopoietic transcriptional regulators have been identified by characterizing factors mediating cell… CONTINUE READING

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A «knockdown» mutation created by cis-element gene targeting reveals the dependence of red blood cell maturation on the level of transcrption factor GATA-1

  • M. A. McDEVITT, R. A. SHIVDASANI, Y. FUJIWARA, H. WANG, S. H. ORKIN
  • Proc. Natl. Acad. Sci. USA
  • 1997
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