Embryonic stem cells and their differentiated derivatives have a fragile immune privilege but still represent novel targets of immune attack.

@article{Wu2008EmbryonicSC,
  title={Embryonic stem cells and their differentiated derivatives have a fragile immune privilege but still represent novel targets of immune attack.},
  author={Douglas C. Wu and Ashleigh Susan Boyd and Kathryn J. Wood},
  journal={Stem cells},
  year={2008},
  volume={26 8},
  pages={1939-50}
}
Embryonic stem cells (ESCs) offer an attractive potential in cell replacement therapy and regenerative medicine because of their inherent plasticity and ability to self-renew. However, the immunological response against transplanted ESC-derived allografts requires further evaluation. In this study, we showed that ESCs expressing the major histocompatibility complex class I molecule H2K(b) escape immune recognition by H2K(b)-reactive CD8(+) T cells, irrespective of H2K(b) expression levels. In… CONTINUE READING

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A comparison of protocols used to generate insulin - producing cell clusters from mouse embryonic

  • P Blyszczuk, C Asbrand, A Rozzo
  • stem cells
  • 2008

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