Embryonic stem cells and embryoid bodies express lymphocyte costimulatory molecules.

@article{Ling1998EmbryonicSC,
  title={Embryonic stem cells and embryoid bodies express lymphocyte costimulatory molecules.},
  author={Vincent Ling and Ray C Munroe and Elizabeth A. K. Murphy and Gary S. Gray},
  journal={Experimental cell research},
  year={1998},
  volume={241 1},
  pages={55-65}
}
Despite the importance of the costimulatory proteins B7-1 (CD80), B7-2 (CD86), and their counterreceptors CD28 and CTLA-4 (CD154) in the regulation of T cell proliferation in the adult immunological system, the initial appearance of these proteins during embryonic development has not been investigated. Using in vitro cultures of undifferentiated mouse embryonic stem (ES) cells and differentiating embryoid bodies as a model of very early embryonic development, we examined these cells for the… CONTINUE READING