Embryonic stem cell self-renewal pathways converge on the transcription factor Tfcp2l1.

  title={Embryonic stem cell self-renewal pathways converge on the transcription factor Tfcp2l1.},
  author={Shoudong Ye and Ping Li and Chang Tong and Qi-Long Ying},
  journal={The EMBO journal},
  volume={32 19},
Mouse embryonic stem cell (mESC) self-renewal can be maintained by activation of the leukaemia inhibitory factor (LIF)/signal transducer and activator of transcription 3 (Stat3) signalling pathway or dual inhibition (2i) of glycogen synthase kinase 3 (Gsk3) and mitogen-activated protein kinase kinase (MEK). Several downstream targets of the pathways involved have been identified that when individually overexpressed can partially support self-renewal. However, none of these targets is shared… CONTINUE READING
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