Embryonic stem cell-derived exosomes promote endogenous repair mechanisms and enhance cardiac function following myocardial infarction.

@article{Khan2015EmbryonicSC,
  title={Embryonic stem cell-derived exosomes promote endogenous repair mechanisms and enhance cardiac function following myocardial infarction.},
  author={Mohsin Khan and Emily Nickoloff and Tatiana Abramova and Jennifer Johnson and Suresh Kumar Verma and Prasanna Krishnamurthy and Alexander Roy Mackie and Erin E. Vaughan and Venkata Naga Srikanth Garikipati and Cynthia Benedict and Veronica Ramirez and Erin Lambers and Aiko Ito and E. Mei Gao and Sol Misener and Timothy S. Luongo and John W. Elrod and Gangjian Qin and Steven R. Houser and Walter J Koch and Raj Kishore},
  journal={Circulation research},
  year={2015},
  volume={117 1},
  pages={52-64}
}
RATIONALE Embryonic stem cells (ESCs) hold great promise for cardiac regeneration but are susceptible to various concerns. Recently, salutary effects of stem cells have been connected to exosome secretion. ESCs have the ability to produce exosomes, however, their effect in the context of the heart is unknown. OBJECTIVE Determine the effect of ESC-derived exosome for the repair of ischemic myocardium and whether c-kit(+) cardiac progenitor cells (CPCs) function can be enhanced with ESC… CONTINUE READING
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