Embryonic stem cell–specific microRNAs promote induced pluripotency

@article{Judson2009EmbryonicSC,
  title={Embryonic stem cell–specific microRNAs promote induced pluripotency},
  author={Robert L Judson and Joshua E Babiarz and Monica Venere and Robert Blelloch},
  journal={Nature Biotechnology},
  year={2009},
  volume={27},
  pages={459-461}
}
This report demonstrates that introduction of microRNAs (miRNAs) specific to embryonic stem cells enhances the production of mouse induced pluripotent stem (iPS) cells. The miRNAs miR-291-3p, miR-294 and miR-295 increase the efficiency of reprogramming by Oct4, Sox2 and Klf4, but not by these factors plus cMyc. cMyc binds the promoter of the miRNAs, suggesting that they are downstream effectors of cMyc during reprogramming. However, unlike cMyc, the miRNAs induce a homogeneous population of iPS… CONTINUE READING
Highly Influential
This paper has highly influenced 27 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 313 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 12 references

Bioinformatics

  • A P Fejes
  • Bioinformatics
  • 2008

Cell Stem Cell

  • T Brambrink
  • Cell Stem Cell
  • 2008

Genes Dev

  • M Eilers, R N Eisenman
  • Genes Dev
  • 2008

Nat. Biotechnol

  • M Nakagawa
  • Nat. Biotechnol
  • 2008

Nat. Genet

  • Y Wang
  • Nat. Genet
  • 2008

Nat. Rev. Genet

  • K W Orford, D T Scadden
  • Nat. Rev. Genet
  • 2008

Nat. Struct. Mol. Biol

  • R Benetti
  • Nat. Struct. Mol. Biol
  • 2008

Nature

  • T S Mikkelsen
  • Nature
  • 2007

Cell

  • P M Voorhoeve
  • Cell
  • 2006

Dev. Cell

  • H B Houbaviy, M F Murray, P A Sharp
  • Dev. Cell
  • 2003

Similar Papers

Loading similar papers…