Embryonic mesoderm cells spread in response to platelet-derived growth factor and signaling by phosphatidylinositol 3-kinase.

@article{Symes1996EmbryonicMC,
  title={Embryonic mesoderm cells spread in response to platelet-derived growth factor and signaling by phosphatidylinositol 3-kinase.},
  author={Karen Symes and Mark Mercola},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 18},
  pages={
          9641-4
        }
}
  • Karen Symes, Mark Mercola
  • Published in
    Proceedings of the National…
    1996
  • Biology, Medicine
  • Abnormal mesoderm movement, leading to defects in axial organization, is observed in mouse and Xenopus laevis embryos deprived of platelet-derived growth factor (PDGF) AA signaling. However, neither the cellular response to PDGF nor the signaling pathways involved are understood. Herein we describe an in vitro assay to examine the direct effect of PDGF AA on aggregates of Xenopus embryonic mesoderm cells. We find that PDGF AA stimulates aggregates to spread on fibronectin. This behavior is… CONTINUE READING

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