Embryonic malformations in rats, resulting from maternal diabetes: preliminary observations.

@article{Deuchar1977EmbryonicMI,
  title={Embryonic malformations in rats, resulting from maternal diabetes: preliminary observations.},
  author={Elizabeth M. Deuchar},
  journal={Journal of embryology and experimental morphology},
  year={1977},
  volume={41},
  pages={93-9}
}
Diabetes mellitus was induced in female Wistar rats by injections of either alloxan or streptozotocin, and their embryos were found to have significantly higher incidences (7.5%) of brain and heart abnormalities (non-closure of neural folds, and deformities of heart chambers) at mid-gestation than controls (2.2%). There were also increased numbers of resorptions (25% in diabetic animals: 7.2% in controls). Both drugs produced similar abnormalities. External and X-ray examination of 488 foetuses… CONTINUE READING