Embryonic lung growth is normal in a cftr-knockout mouse model.

  title={Embryonic lung growth is normal in a cftr-knockout mouse model.},
  author={Helen L. Wallace and Marilyn Gwen Connell and Paul D Losty and Edwin Chitran Jesudason and Kevin W. Southern},
  journal={Experimental lung research},
  volume={34 10},
The role of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel in embryonic lung growth remains uncertain. The authors used an established embryonic lung culture model to investigate the impact of cftr knockout on lung growth, airway peristalsis, and airway smooth muscle (ASM) distribution. Lung area, perimeter, lung bud count, and frequency of contraction were similar in wild-type (cftr +/+) and cftr knockout mice (cftr -/-). The percentage of mitotic cells was… CONTINUE READING

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