Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene

@article{Yergeau1997EmbryonicLA,
  title={Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene},
  author={Donald Albert Yergeau and Christopher J. Hetherington and Qing Wang and Pu Zhang and Arlene H Sharpe and Michael K. Binder and Miguel Mar{\'i}n-Padilla and Daniel G Tenen and Nancy A Speck and Dong-Er Zhang},
  journal={Nature Genetics},
  year={1997},
  volume={15},
  pages={303-306}
}
Acute myeloid leukaemia (AMI) is a major haematopoietic malignancy characterized by the proliferation of a malignant clone of myeloid progenitor cells1,2. A reciprocal translocation, t(8;21)(q22;q22), observed in the leukaemic cells of approximately 40% of patients with the M2 subtype of AMI disrupts both the AML1 (CBFA2) gene on chromosome 21 and the ETO (MTG8) gene on chromosome 8 (refs 3–5). A chimaeric protein is synthesized from one of the derivative chromosomes that contains the N… CONTINUE READING
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