Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene.

@article{Mikula2001EmbryonicLA,
  title={Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene.},
  author={Mario Mikula and Martin Schreiber and Zvenyslava Husak and Lucia Kucerova and Jochen R{\"u}th and Rotraud Wieser and Kurt Zatloukal and Hartmut Beug and Erwin F Wagner and Manuela Baccarini},
  journal={The EMBO journal},
  year={2001},
  volume={20 8},
  pages={1952-62}
}
The Raf kinases play a key role in relaying signals elicited by mitogens or oncogenes. Here, we report that c-raf-1(-/-) embryos are growth retarded and die at midgestation with anomalies in the placenta and in the fetal liver. Although hepatoblast proliferation does not appear to be impaired, c-raf-1(-/-) fetal livers are hypocellular and contain numerous apoptotic cells. Similarly, the poor proliferation of Raf-1(-/-) fibroblasts and hematopoietic cells cultivated in vitro is due to an… CONTINUE READING

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