Embryonic lethality, decreased erythropoiesis, and defective octamer-dependent promoter activation in Oct-1-deficient mice.

@article{Wang2004EmbryonicLD,
  title={Embryonic lethality, decreased erythropoiesis, and defective octamer-dependent promoter activation in Oct-1-deficient mice.},
  author={Victoria E H Wang and Tara Schmidt and Jianzhu Chen and Phillip A. Sharp and Dean Tantin},
  journal={Molecular and cellular biology},
  year={2004},
  volume={24 3},
  pages={1022-32}
}
Oct-1 is a sequence-specific DNA binding transcription factor that is believed to regulate a large group of tissue-specific and ubiquitous genes. Both Oct-1 and the related but tissue-restricted Oct-2 protein bind to a DNA sequence termed the octamer motif (5'-ATGCAAAT-3') with equal affinity in vitro. To address the role of Oct-1 in vivo, an Oct-1-deficient mouse strain was generated by gene targeting. Oct-1-deficient embryos died during gestation, frequently appeared anemic, and suffered from… CONTINUE READING