Embryonic imprinting perturbations do not originate from superovulation-induced defects in DNA methylation acquisition.

@article{Denomme2011EmbryonicIP,
  title={Embryonic imprinting perturbations do not originate from superovulation-induced defects in DNA methylation acquisition.},
  author={Michelle M. Denomme and Liyue Zhang and Mellissa R W Mann},
  journal={Fertility and sterility},
  year={2011},
  volume={96 3},
  pages={
          734-738.e2
        }
}
OBJECTIVE To investigate whether superovulation disrupts maternal imprint acquisition in oocytes. DESIGN Animal model. SETTING Academic institute. ANIMAL(S) Spontaneously ovulated and superovulated mice. INTERVENTION(S) Low and high hormone dosage treatments were administered to females, and ovulated metaphase II oocytes were collected. MAIN OUTCOME MEASURE(S) Imprinted DNA methylation was analyzed at Snrpn, Kcnq1ot1, Peg3, and H19 in individual oocytes. RESULT(S) Examination of 125… CONTINUE READING
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