Embryonic epsilon and gamma globin genes of a prosimian primate (Galago crassicaudatus). Nucleotide and amino acid sequences, developmental regulation and phylogenetic footprints.

@article{Tagle1988EmbryonicEA,
  title={Embryonic epsilon and gamma globin genes of a prosimian primate (Galago crassicaudatus). Nucleotide and amino acid sequences, developmental regulation and phylogenetic footprints.},
  author={Danilo A. Tagle and Ben F. Koop and Morris Goodman and Jerry L. Slightom and David L. Hess and Richard T. Jones},
  journal={Journal of molecular biology},
  year={1988},
  volume={203 2},
  pages={
          439-55
        }
}
Sequence analysis of epsilon and gamma genes and encoded globins and high-pressure liquid chromatography analysis of globin compositions in blood hemolysates obtained from embryos, fetuses and adults show that the prosimian primate Galago crassicaudatus expresses its epsilon and gamma genes only embryonically. Since rabbit, mouse and galago all have embryonic gamma genes but simian primates have fetal gamma genes, we conclude that gamma E evolved into gamma F in stem-simians. An elevated non… CONTINUE READING
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