Embryonic development of circadian oscillations in the mouse hypothalamus.

  title={Embryonic development of circadian oscillations in the mouse hypothalamus.},
  author={Daniel Wreschnig and Hamid Dolatshad and Fred C. Davis},
  journal={Journal of biological rhythms},
  volume={29 4},
Circadian rhythms in mammals are regulated by the hypothalamic suprachiasmatic nucleus (SCN). The generation of circadian oscillations is a cell-autonomous property, and coupling among cells is essential for the SCN to function as a pacemaker. The development of SCN anatomy and cytology has been extensively studied, but the point in development when the SCN first has the capacity to generate circadian oscillations has not been established. We therefore examined the development of circadian… CONTINUE READING