Embryonic development in the reduced folate carrier knockout mouse is modulated by maternal folate supplementation.

@article{Waes2008EmbryonicDI,
  title={Embryonic development in the reduced folate carrier knockout mouse is modulated by maternal folate supplementation.},
  author={Jan{\'e}e Gelineau-van Waes and Steven Heller and Linda K. Bauer and Justin Wilberding and Joyce R. Maddox and Francisco Alem{\'a}n and Thomas H. Rosenquist and Richard H. Finnell},
  journal={Birth defects research. Part A, Clinical and molecular teratology},
  year={2008},
  volume={82 7},
  pages={
          494-507
        }
}
BACKGROUND The reduced folate carrier (RFC1) is a ubiquitously expressed integral membrane protein that mediates delivery of 5-methyltetrahydrofolate into mammalian cells. In this study, embryonic/fetal development is characterized in an RFC1 knockout mouse model in which pregnant dams receive different levels of folate supplementation. METHODS RFC1(+/-) males were mated to RFC1(+/-) females, and pregnant dams were treated with vehicle (control) or folic acid (25 or 50 mg/kg) by daily… CONTINUE READING

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