Embryonic Stem Cells As an Alternate Marrow Donor Source : Engraftment without Graft-Versus-Host Disease

@inproceedings{Burt2004EmbryonicSC,
  title={Embryonic Stem Cells As an Alternate Marrow Donor Source : Engraftment without Graft-Versus-Host Disease},
  author={Richard K. Burt and Larissa Verda and Duck-An Kim and Yu Oyama and Kehuan Luo and Charles Link},
  year={2004}
}
A single embryonic stem cell (ESC) line can be repetitively cryopreserved, thawed, expanded, and differentiated into various cellular components serving as a potentially renewable and wellcharacterized stem cell source. Therefore, we determined whether ESCs could be used to reconstitute marrow and blood in major histocompatibility complex (MHC)-mismatched mice. To induce differentiation toward hematopoietic stem cells (HSCs) in vitro, ESCs were cultured in methylcellulose with stem cell factor… CONTINUE READING

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