Embryonic Mammary Gland Development; a Domain of Fundamental Research with High Relevance for Breast Cancer Research

@article{Howard2013EmbryonicMG,
  title={Embryonic Mammary Gland Development; a Domain of Fundamental Research with High Relevance for Breast Cancer Research},
  author={Beatrice A. Howard and Jacqueline M. Veltmaat},
  journal={Journal of Mammary Gland Biology and Neoplasia},
  year={2013},
  volume={18},
  pages={89-91}
}
Mammary gland development is often presented as a series of events happening during puberty, pregnancy, lactation and involution; even though it starts in utero, and extensive morphogenetic events occur prior to birth. During the last century, research on the embryonic phase of mammary gland development received little attention as lactation and breast cancer investigations experienced greater emphasis. Nonetheless, important contributions were made during the 1950’s–1980’s by Boris Balinsky… 
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References

SHOWING 1-2 OF 2 REFERENCES
Human breast development.
Human Breast Development
TLDR
The current state of knowledge of human breast development is indicated and some of the main similarities and differences with the rodent, the main animal model are indicated.