Embryonic Lethality in Mice Lacking the Nuclear Factor of Activated T Cells 5 Protein Due to Impaired Cardiac Development and Function

@article{Mak2011EmbryonicLI,
  title={Embryonic Lethality in Mice Lacking the Nuclear Factor of Activated T Cells 5 Protein Due to Impaired Cardiac Development and Function},
  author={M. Mak and K. Lam and P. Chan and Yu Bond Lau and W. Tang and P. Yeung and B. C. Ko and S. Chung and Sookja K. Chung},
  journal={PLoS ONE},
  year={2011},
  volume={6}
}
Nuclear factor of activated T cells 5 protein (NFAT5) is thought to be important for cellular adaptation to osmotic stress by regulating the transcription of genes responsible for the synthesis or transport of organic osmolytes. It is also thought to play a role in immune function, myogenesis and cancer invasion. To better understand the function of NFAT5, we developed NFAT5 gene knockout mice. Homozygous NFAT5 null (NFAT5−/−) mouse embryos failed to develop normally and died after 14.5 days of… Expand
Generation of a conditional knockout allele for the NFAT5 gene in mice
NFAT5 regulates the canonical Wnt pathway and is required for cardiomyogenic differentiation.
NFAT5-mediated CACNA1C expression is critical for cardiac electrophysiological development and maturation
Potential Role of Gene Regulator NFAT5 in the Pathogenesis of Diabetes Mellitus
NFAT5 Has a Job in the Brain
...
1
2
3
4
...

References

SHOWING 1-10 OF 32 REFERENCES
Loss of NFAT5 results in renal atrophy and lack of tonicity-responsive gene expression.
NFAT5/TonEBP mutant mice define osmotic stress as a critical feature of the lymphoid microenvironment.
The Osmoprotective Function of the NFAT5 Transcription Factor in T Cell Development and Activation1
Mouse TonEBP-NFAT5: expression in early development and alternative splicing.
The NFAT-Related Protein NFATL1 (TonEBP/NFAT5) Is Induced Upon T Cell Activation in a Calcineurin-Dependent Manner1
Transcription factors of the NFAT family: regulation and function.
...
1
2
3
4
...