Embryonal carcinoma P19 cells produce erythropoietin constitutively but express lactate dehydrogenase in an oxygen-dependent manner.

@article{Kambe1998EmbryonalCP,
  title={Embryonal carcinoma P19 cells produce erythropoietin constitutively but express lactate dehydrogenase in an oxygen-dependent manner.},
  author={Taiho Kambe and Joji Tada and Mariko Chikuma and Satohiro Masuda and Masataka Nagao and Tomoko Tsuchiya and Peter J Ratcliffe and Ryuzo Sasaki},
  journal={Blood},
  year={1998},
  volume={91 4},
  pages={1185-95}
}
Embryonic stem cells and embryonal carcinoma P19 cells produce erythropoietin (Epo) in an oxygen-independent manner, although lactate dehydrogenase A (LDHA) is hypoxia-inducible. To explore this paradox, we studied the operation of cis-acting sequences from these genes in P19 and Hep3B cells. The Epo gene promoter and 3' enhancer from P19 cells conveyed hypoxia-inducible responses in Hep3B cells but not in P19 cells. Together with DNA sequencing and the normal transcription start site of P19… CONTINUE READING
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