Embryological-origin-dependent differences in homeobox expression in adult aorta: role in regional phenotypic variability and regulation of NF-κB activity.

@article{TriguerosMotos2013Embryologicalorigindependen,
  title={Embryological-origin-dependent differences in homeobox expression in adult aorta: role in regional phenotypic variability and regulation of NF-κB activity.},
  author={Laia Trigueros-Motos and Jos{\'e} Mar{\'i}a Gonz{\'a}lez-Granado and Christine Cheung and Patricia A Fernandez and F{\'a}tima S{\'a}nchez-Cabo and Ana Dopazo and Sanjay Sinha and Vicente Andr{\'e}s},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2013},
  volume={33 6},
  pages={1248-56}
}
OBJECTIVE Different vascular beds show differing susceptibility to the development of atherosclerosis, but the molecular mechanisms underlying these differences are incompletely understood. This study aims to identify factors that contribute to the phenotypic heterogeneity of distinct regions of the adult vasculature. APPROACH AND RESULTS High-throughput mRNA profiling in adult mice reveals higher expression of the homeobox paralogous genes 6 to 10 (Hox6-10) in the athero-resistant thoracic… CONTINUE READING

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