Embryological and molecular investigations of parental imprinting on mouse chromosome 7

@article{FergusonSmith1991EmbryologicalAM,
  title={Embryological and molecular investigations of parental imprinting on mouse chromosome 7},
  author={Anne C Ferguson-Smith and Bruce M. Cattanach and Sheila C. Barton and Colin V. Beechey and M. Azim Surani},
  journal={Nature},
  year={1991},
  volume={351},
  pages={667-670}
}
MOUSE embryos with duplications of whole maternal (partheno-genetic and gynogenetic) or paternal (androgenetic) genomes show reciprocal phenotypes and do not develop to term1,2. Genetic complementation has identified the distal region of chromosome 7 (Chr 7) as one of the regions for which both a maternal and paternal chromosome copy are essential for normal development, presumably because of the presence of imprinted genes whose expression is dependent on their parental origin3,4. Embryos with… CONTINUE READING

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