Embryoid body morphology influences diffusive transport of inductive biochemicals: a strategy for stem cell differentiation.

@article{Sachlos2008EmbryoidBM,
  title={Embryoid body morphology influences diffusive transport of inductive biochemicals: a strategy for stem cell differentiation.},
  author={Eleftherios Sachlos and Debra T. Auguste},
  journal={Biomaterials},
  year={2008},
  volume={29 34},
  pages={4471-80}
}
Differentiation of human embryonic stem (hES) cells into cells for regenerative medicine is often initiated by embryoid body (EB) formation. EBs may be treated with soluble biochemicals such as cytokines, growth factors and vitamins to induce differentiation. A scanning electron microscopy analysis, conducted over 14 days, revealed time-dependent changes in EB structure which led to the formation of a shell that significantly reduced the diffusive transport of a model molecule (374 Da) by >80… CONTINUE READING
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