Embryogenesis of the bursa of Fabricius: stem cell, microenvironment, and receptor-paracrine pathways.

@article{Glick1995EmbryogenesisOT,
  title={Embryogenesis of the bursa of Fabricius: stem cell, microenvironment, and receptor-paracrine pathways.},
  author={Bruce Glick},
  journal={Poultry science},
  year={1995},
  volume={74 3},
  pages={419-26}
}
The bursa of Fabricius is an ideal model system to answer the plethora of questions related to the origin of B cells and microenvironmental issues leading to the education of the stem cell. Prior to the 1960s, lymphocytes were thought to be derived from epithelial or mesenchymal cells. Later work demonstrated the bloodborne nature of the stem cell contributing to B cells. Stem cells entered the bursa of quail and chicken between 7 and 11 and 7.5 and 14 d of embryogenesis, respectively… CONTINUE READING
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