Embryo implantation after biopsy of one or two cells from cleavage-stage embryos with a view to preimplantation genetic diagnosis.

@article{Velde2000EmbryoIA,
  title={Embryo implantation after biopsy of one or two cells from cleavage-stage embryos with a view to preimplantation genetic diagnosis.},
  author={Hilde van de Velde and Anick De Vos and Karen Dora Sermon and Cath{\'e}rine Staessen and Martine De Rycke and Elvire van Assche and Willy Lissens and Mark Vandervorst and Heidi Van Ranst and Inge Liebaers and Andr{\'e} Van Steirteghem},
  journal={Prenatal diagnosis},
  year={2000},
  volume={20 13},
  pages={1030-7}
}
Preimplantation genetic diagnosis (PGD) can be offered as an alternative to prenatal diagnosis (PND) to couples at risk of having a child with a genetic disease. The affected embryos are detected before implantation by fluorescent in situ hybridisation (FISH) for sexing (X-linked diseases) and chromosomal disorders (numerical and structural) or by polymerase chain reaction (PCR) for monogenic disorders (including some X-linked diseases). The accuracy and reliability of the diagnosis is… CONTINUE READING