Embryo-fetal development studies with the dietary supplement vinpocetine in the rat and rabbit.

@article{Catlin2018EmbryofetalDS,
  title={Embryo-fetal development studies with the dietary supplement vinpocetine in the rat and rabbit.},
  author={Natasha R. Catlin and Suramya Waidyanatha and Eve Mylchreest and Lutfiya Miller-Pinsler and Helen C. Cunny and Paul M. D. Foster and Vicki Sutherland and Barry S McIntyre},
  journal={Birth defects research},
  year={2018},
  volume={110 10},
  pages={
          883-896
        }
}
Dietary supplement and natural product use is increasing within the United States, resulting in growing concern for exposure in vulnerable populations, including young adults and women of child-bearing potential. Vinpocetine is a semisynthetic derivative of the Vinca minor extract, vincamine. Human exposure to vinpocetine occurs through its use as a dietary supplement for its purported nootropic and neuroprotective effects. To investigate the effects of vinpocetine on embryo-fetal development… Expand
2 Citations
Response to the letter to the editor for embryo‐fetal development studies with the dietary supplement vinpocetine in the rat and rabbit
TLDR
The conclusion of exposure-dependent increases in the incidences of ventricular septum defects (VSD) and full supernumerary thoracolumbar ribs (SR) is based on dose–response, careful comparison with historical control, and statistical testing. Expand
Analysis of proportional data in reproductive and developmental toxicity studies: Comparison of sensitivities of logit transformation, arcsine square root transformation, and nonparametric analysis
TLDR
In developmental and reproductive toxicity studies, analysis of litter‐based binary endpoints is complex in that littermates often are not entirely independent of one another and data are typically analyzed by nonparametric methods, arcsine square root transformation, or logit transformation. Expand

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