Eleven cases with severe nasal hemorrhage caused by diseases of the vascular system (Rendu-Osler-Weber disease) are analysed. The results of angiography in patients with this pathological condition and the angiographic picture of changes in the branches of the maxillary artery which caused bleeding are described. The emergency therapeutic measures in severe epistaxis and the methods of surgical treatment are discussed. Twenty-five endovascular operations were performed. The authors demonstrated the possibility of superselective catheterization of the external carotid artery branches with subsequent embolization in arresting severe bleeding from the nose in hemorrhagic angiomatosis.