Embelin suppresses pancreatic cancer growth by modulating tumor immune microenvironment.

@article{Marsh2014EmbelinSP,
  title={Embelin suppresses pancreatic cancer growth by modulating tumor immune microenvironment.},
  author={J Lawrence Marsh and Christopher P. Jackman and Su-Ni Tang and Sharmila Shankar and R. K Srivastava},
  journal={Frontiers in bioscience},
  year={2014},
  volume={19},
  pages={
          113-25
        }
}
Since pancreatic carcinoma is largely refractory to conventional therapies, development of novel agents is required for the effective treatment of pancreatic cancer. The objective of this paper was to examine the molecular mechanisms by which embelin inhibited human pancreatic cancer growth in mice by modulating tumor immune microenvironment. Embelin inhibited PANC-1 tumor growth, angiogenesis, and metastasis which were associated with suppression of Akt and Sonic Hedgehog (Shh) pathways… 

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