Embedded cholesterol in the nicotinic acetylcholine receptor.

  title={Embedded cholesterol in the nicotinic acetylcholine receptor.},
  author={Grace Brannigan and J{\'e}r{\^o}me H{\'e}nin and Richard Law and Roderic G. Eckenhoff and Michael L. Klein},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={105 38},
The nicotinic acetylcholine receptor (nAChR) is a cation-selective channel central to both neuronal and muscular processes and is considered the prototype for ligand-gated ion channels, motivating a structural determination effort that spanned several decades [Unwin N (2005) Refined structure of the nicotinic acetylcholine receptor at 4 A resolution. J Mol Biol 346:967-989]. Purified nAChR must be reconstituted in a mixture containing cholesterol to function. Proposed modes of interaction… CONTINUE READING


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