Elution of antispectrin antibodies from red cells in homozygous beta-thalassaemia.

@article{Wiener1986ElutionOA,
  title={Elution of antispectrin antibodies from red cells in homozygous beta-thalassaemia.},
  author={Edith Wiener and Nevin C. Hughes-Jones and William Irish and S M D Nalini Wickramasinghe},
  journal={Clinical and experimental immunology},
  year={1986},
  volume={63 3},
  pages={680-6}
}
It is well-established that autoantibodies against red cell membrane antigens, such as spectrin are present in plasma of humans and animals. It is shown here that antispectrin IgG antibodies can be eluted from the red cells of patients with beta-thalassaemia intermedia. It is suggested that these antibodies could play a part in the increased rate of destruction of red cells in homozygous beta-thalassemia, either by reacting with spectrin which is abnormally exposed on the red cell surface or by… CONTINUE READING