Elucidation of the structure of SA-FF22, a lanthionine-containing antibacterial peptide produced by Streptococcus pyogenes strain FF22.

@article{Jack1994ElucidationOT,
  title={Elucidation of the structure of SA-FF22, a lanthionine-containing antibacterial peptide produced by Streptococcus pyogenes strain FF22.},
  author={Ralph Wilson Jack and Alan Carne and J{\"o}rg Metzger and Sandra Stefanovic and Hans Georg Sahl and Giman Jung and John Robert Tagg},
  journal={European journal of biochemistry},
  year={1994},
  volume={220 2},
  pages={455-62}
}
The antibacterial peptide SA-FF22, produced by the pathogen Streptococcus pyogenes strain FF22 was purified and features of its primary and secondary structure were characterised. Mass spectrometry demonstrated the pure peptide had a mass of 2794Da while, amino acid analysis revealed the presence of the unusual, thioether amino acids lanthionine and 3-methyllanthionine; thus SA-FF22 is a member of the group of antibacterial polypeptides termed lantibiotics. Furthermore, amino acid sequencing… CONTINUE READING

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