Elucidation of the neurobiology of depression: insights from a novel genetic animal model

  title={Elucidation of the neurobiology of depression: insights from a novel genetic animal model},
  author={Gal Yadid and Rachel A Nakash and I. Deri and Grin Tamar and Abraham Zangen},
  journal={Progress in Neurobiology},
Development of drugs for the effective treatment of depressive disorders requires elucidation of factors that are critical for clinically antidepressant effects. During the past 4 years, we have studied in situ neurochemical alterations in the brain that may underlie depressive behavior. This was achieved using the genetically-selected Flinders Sensitive Line (FSL) of rats (a unique animal model of depression), before and after chronic antidepressant treatment. This line of rats exhibits… CONTINUE READING
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Increased stress-evoked nitric oxide signalling in the Flinders sensitive line (FSL) rat: a genetic animal model of depression.

The international journal of neuropsychopharmacology • 2010
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