Elucidation of the metabolic pathways and the resulting multiple metabolites of almorexant, a dual orexin receptor antagonist, in humans.

Abstract

Almorexant [(2R)-2-{(1S)-6, 7-dimethoxy-1-[2-(4-trifluoromethyl-phenyl)-ethyl]-3,4-dihydro-1H-isoquinolin-2-yl}-N-methyl-2-phenyl-acetamide], a tetrahydroisoquinoline derivative, is a dual orexin receptor antagonist with sleep-promoting properties in both animals and humans. This study investigated the disposition, metabolism, and elimination of almorexant… (More)
DOI: 10.1124/dmd.112.050120

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Cite this paper

@article{Dingemanse2013ElucidationOT, title={Elucidation of the metabolic pathways and the resulting multiple metabolites of almorexant, a dual orexin receptor antagonist, in humans.}, author={J Gertjan Dingemanse and P. Hoever and Matthias Hoch and Alexander S Treiber and Winfried Wagner-Redeker and Tommaso Miraval and G{\'e}rard Hopfgartner and Kasra Shakeri-Nejad}, journal={Drug metabolism and disposition: the biological fate of chemicals}, year={2013}, volume={41 5}, pages={1046-59} }