Elucidation of the basic three-dimensional structure of type I interferons and its functional and evolutionary implications.

@article{Mitsui1997ElucidationOT,
  title={Elucidation of the basic three-dimensional structure of type I interferons and its functional and evolutionary implications.},
  author={Yukio Mitsui and Toshiya Senda},
  journal={Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research},
  year={1997},
  volume={17 6},
  pages={
          319-26
        }
}
The scientific and personal backgrounds of the crystallographic elucidation of the three-dimensional structure of murine interferon-beta (Mu-IFN-beta) are described. This structure, elucidated in 1990, is still the only experimentally determined structure for type I IFNs. Model-building studies for various type I IFNs based on the Mu-IFN-beta structure and the arguments on the receptor-binding epitopes appearing since then are reviewed. An updated set of a table and a figure demonstrating a… CONTINUE READING