Elucidation of the Phase I and Phase II metabolic pathways of (±)-4'-methylmethcathinone (4-MMC) and (±)-4'-(trifluoromethyl)methcathinone (4-TFMMC) in rat liver hepatocytes using LC-MS and LC-MS².

Abstract

(±)-4'-Methylmethcathinone hydrochloride [(±)-mephedrone, 4-MMC] is a synthetic "legal high", with a classical cathinone structure similar to methcathinone. In this study, the in vitro metabolism of 4-MMC was investigated in Sprague-Dawley rat hepatocytes to characterise the associated Phase I and II metabolites. 4-MMC was incubated with rat liver… (More)
DOI: 10.1016/j.jpba.2012.08.015

Topics

Cite this paper

@article{Khreit2013ElucidationOT, title={Elucidation of the Phase I and Phase II metabolic pathways of (±)-4'-methylmethcathinone (4-MMC) and (±)-4'-(trifluoromethyl)methcathinone (4-TFMMC) in rat liver hepatocytes using LC-MS and LC-MS².}, author={Osama I G Khreit and Mary Helen Grant and Tong Zhang and Catherine J. Henderson and David G. Watson and Oliver B Sutcliffe}, journal={Journal of pharmaceutical and biomedical analysis}, year={2013}, volume={72}, pages={177-85} }