Elucidation of the Binding Mechanism of Coumarin Derivatives with Human Serum Albumin

  title={Elucidation of the Binding Mechanism of Coumarin Derivatives with Human Serum Albumin},
  author={Archit Garg and Darla Mark Manidhar and Mahesh Gokara and Chandramouli Malleda and Cirandur Suresh Reddy and Rajagopal Subramanyam},
  booktitle={PloS one},
Coumarin is a benzopyrone which is widely used as an anti-coagulant, anti-oxidant, anti-cancer and also to cure arthritis, herpes, asthma and inflammation. Here, we studied the binding of synthesized coumarin derivatives with human serum albumin (HSA) at physiological pH 7.2 by using fluorescence spectroscopy, circular dichroism spectroscopy, molecular docking and molecular dynamics simulation studies. By addition of coumarin derivatives to HSA the maximum fluorescence intensity was reduced due… CONTINUE READING
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Synthesis of New 8-Formyl-4methyl-7-hydroxy Coumarin Derivatives

DM Manidhar, K Uma Maheswara Rao, N Bakthavatchala Reddy, C Syamasundar, C Suresh Reddy
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