Elucidation of spheroid formation with and without the extrusion step

@article{Liew2007ElucidationOS,
  title={Elucidation of spheroid formation with and without the extrusion step},
  author={Celine Valeria Liew and Siang Meng Chua and Paul Wan Sia Heng},
  journal={AAPS PharmSciTech},
  year={2007},
  volume={8},
  pages={E70-E81}
}
Spheroid formation mechanisms were investigated using extrusion-spheronization (ES) and rotary processing (RP). Using ES (cross-hatch), ES (teardrop), and RP (teardrop), spheroids with similar mass median diameter (MMD) and span were produced using equivalent formulation and spheronization conditions. During spheronization, the teardrop-studded rotating frictional surface, with increased peripheral tip speed and duration, produced spheroids of equivalent MMD and span to those produced by the… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 24 references

Formulation variables. In: Sellassie IG, ed

MR Harris, IG Sellassie
Pharmaceutical Pelletization Technology • 1989
View 4 Excerpts
Highly Influenced

Internal and external structure of pellets made in a rotary processor

J Vertommen, P Rombaut, R. Kinget
Int J Pharm. 1998;161: 225Y236. AAPS PharmSciTech • 2007
View 1 Excerpt

A study of the effects of the physical characteristics of microcrystalline cellulose on performance in extrusion spheronization

Heng PWS, Koo OMY
Pharm Res • 2001

Comparison of rotor direct pelletization (fluid bed) and extrusion/spheronization method for pellet production

R Pisek, J Sirca, G Svanjak, S. Sricic
Pharm Ind. 2001;63:1202Y1209 • 2001
View 1 Excerpt

Nucleation, growth and breakdown phenomena in agitated wet granulation processes: a review

SM Iveson, JD Litster, K Hapgood, BJ. Ennis
Powder Technol • 2001
View 2 Excerpts

Agglomeration behaviour of powders in a Lödige mixer granulator

F Hoornaert, PAL Wauters, GMH Meesters, SE Pratsinis, B. Scarlett
Powder Technol • 1998
View 1 Excerpt

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