Elucidation of spheroid formation with and without the extrusion step

  title={Elucidation of spheroid formation with and without the extrusion step},
  author={Celine Valeria Liew and Siang Meng Chua and Paul Wan Sia Heng},
  journal={AAPS PharmSciTech},
Spheroid formation mechanisms were investigated using extrusion-spheronization (ES) and rotary processing (RP). Using ES (cross-hatch), ES (teardrop), and RP (teardrop), spheroids with similar mass median diameter (MMD) and span were produced using equivalent formulation and spheronization conditions. During spheronization, the teardrop-studded rotating frictional surface, with increased peripheral tip speed and duration, produced spheroids of equivalent MMD and span to those produced by the… CONTINUE READING


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