Elucidation of post-PKS tailoring steps involved in landomycin biosynthesis.

@article{Kharel2012ElucidationOP,
  title={Elucidation of post-PKS tailoring steps involved in landomycin biosynthesis.},
  author={M. Kharel and Pallab Pahari and K. Shaaban and Guojun Wang and Caleb Morris and J. Rohr},
  journal={Organic \& biomolecular chemistry},
  year={2012},
  volume={10 21},
  pages={
          4256-65
        }
}
The functional roles of all proposed enzymes involved in the post-PKS redox reactions of the biosynthesis of various landomycin aglycones were thoroughly studied, both in vivo and in vitro. The results revealed that LanM2 acts as a dehydratase and is responsible for concomitant release of the last PKS-tethered intermediate to yield prejadomycin (10). Prejadomycin (10) was confirmed to be a general pathway intermediate of the biosynthesis. Oxygenase LanE and the reductase LanV are sufficient to… Expand
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