Elucidation of phenotypic adaptations: Molecular analyses of dim-light vision proteins in vertebrates.

@article{Yokoyama2008ElucidationOP,
  title={Elucidation of phenotypic adaptations: Molecular analyses of dim-light vision proteins in vertebrates.},
  author={Shozo Yokoyama and Takashi Tada and Huan Zhang and Lyle Britt},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 36},
  pages={13480-5}
}
Vertebrate ancestors appeared in a uniform, shallow water environment, but modern species flourish in highly variable niches. A striking array of phenotypes exhibited by contemporary animals is assumed to have evolved by accumulating a series of selectively advantageous mutations. However, the experimental test of such adaptive events at the molecular level is remarkably difficult. One testable phenotype, dim-light vision, is mediated by rhodopsins. Here, we engineered 11 ancestral rhodopsins… CONTINUE READING
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