Elucidation of a novel polypeptide cross-link involving 3-hydroxykynurenine.

@article{Aquilina1999ElucidationOA,
  title={Elucidation of a novel polypeptide cross-link involving 3-hydroxykynurenine.},
  author={J. A. Aquilina and J. Carver and R. Truscott},
  journal={Biochemistry},
  year={1999},
  volume={38 35},
  pages={
          11455-64
        }
}
3-Hydroxykynurenine, a metabolite of tryptophan, is a powerful antioxidant and neurotoxin. The neurotoxicity results from the oxidation of 3-hydroxykynurenine, and hydroxyl radicals, formed via H(2)O(2), may also be implicated [Okuda, S., Nishiyama, N., Saito, H. , and Katsuki, H. (1996) Proc. Natl. Acad. Sci. U.S.A. 93, 12553-12558]. Oxidation of o-aminophenols, such as 3-hydroxykynurenine, also results in the formation of highly reactive quinonimines. Thus, one possible consequence of 3… Expand
A general mechanism of polypeptide cross-linking by 3-hydroxykynurenine.
  • J. A. Aquilina
  • Biology, Medicine
  • Redox report : communications in free radical research
  • 1999
3-Hydroxykynurenine-mediated Modification of Human Lens Proteins
Human α-1-Microglobulin Is Covalently Bound to Kynurenine-derived Chromophores*
The presence of a human UV filter within the lens represents an oxidative stress.
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