Elucidation of a novel Vibrio cholerae lipid A secondary hydroxy-acyltransferase and its role in innate immune recognition

@inproceedings{Hankins2011ElucidationOA,
  title={Elucidation of a novel Vibrio cholerae lipid A secondary hydroxy-acyltransferase and its role in innate immune recognition},
  author={Jessica V Hankins and James A Madsen and David K Giles and Brandon M. Childers and Karl Klose and Jennifer S Brodbelt and M. Stephen Trent},
  booktitle={Molecular microbiology},
  year={2011}
}
Similar to most Gram-negative bacteria, the outer leaflet of the outer membrane of Vibrio cholerae is comprised of lipopolysaccharide. Previous reports have proposed that V. cholerae serogroups O1 and O139 synthesize structurally different lipid A domains, which anchor lipopolysaccharide within the outer membrane. In the current study, intact lipid A species of V. cholerae O1 and O139 were analysed by mass spectrometry. We demonstrate that V. cholerae serogroups associated with human disease… CONTINUE READING